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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO

N-carb-L-Asp + H+ → (S)-DHO + H2O

Reactome: R-HSA-73571
Compartment: cytosol
Rhea: RHEA:24298

Inputs

N-carb-L-AspCHEBI:32814, C5H6N2O5, cytosol
H+CHEBI:15378, H, cytosol

Outputs

(S)-DHOCHEBI:30864, C5H5N2O4, cytosol
H2OCHEBI:15377, H2O, cytosol

Catalysed by

dihydroorotase activity of CAD hexamer [cytosol]EC 3.5.2.3

Literature

Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis Biochem Biophys Res Commun, 1996