GAR + 10-Formyl-THF => FGAR + THF

PRGA + 10-formyl-THF → N-Formyl-GAR + THF + H+

Reactome

R-HSA-73813

Compartment

cytosol

Rhea

None recorded

Catalysed by

• phosphoribosylglycinamide formyltransferase activity of GART [cytosol]EC 2.1.2.2; UniProt P22102

Literature

1. De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementation in E. coli Nucleic Acids Res, 1990
2. Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR Biochemistry, 2002
3. Localization of GAR transformylase in Escherichia coli and mammalian cells Proc Natl Acad Sci USA, 2001
4. Reversible compartmentalization of de novo purine biosynthetic complexes in living cells Science, 2008