CAD hexamer transforms CAP to N-carb-L-Asp

CAP + L-Asp → N-carb-L-Asp + Pi + H+

Reactome

R-HSA-73573

Compartment

cytosol

Rhea

RHEA:20014

Catalysed by

• aspartate carbamoyltransferase activity of CAD hexamer [cytosol]EC 2.1.3.2

Literature

1. Control of pyrimidine biosynthesis in human lymphocytes. Simultaneous increase in activities of glutamine-utilizing carbamyl phosphate synthetase and aspartate transcarbamylase in phytohemagglutinin-stimulated human peripheral lymphocytes and their enzyme co-purification J Biol Chem, 1973
2. Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis Biochem Biophys Res Commun, 1996
3. Oligomeric structure of the multifunctional protein CAD that initiates pyrimidine biosynthesis in mammalian cells Proc Natl Acad Sci USA, 1985