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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]

H2O + IMP + NAD+ → H+ + NADH + XMP

Reactome: R-HSA-73794
Compartment: cytosol
Rhea: RHEA:11709

Inputs

H2OCHEBI:15377, H2O, cytosol
IMPCHEBI:58053, C10H11N4O8P, cytosol
NAD+CHEBI:57540, C21H26N7O14P2, cytosol

Outputs

H+CHEBI:15378, H, cytosol
NADHCHEBI:57945, C21H27N7O14P2, cytosol
XMPCHEBI:57464, C10H11N4O9P, cytosol

Catalysed by

IMP dehydrogenase activity of IMPDH tetramers [cytosol]EC 1.1.1.205

Literature

Characterization of human type I and type II IMP dehydrogenases J Biol Chem, 1993