UMPS dimer decarboxylates OMP to UMP
OMP + H+ → UMP + CO2
- Reactome
- R-HSA-73564
- Compartment
- cytosol
- Rhea
- RHEA:11597
Inputs
- OMPCHEBI:57538, C10H10N2O11P, cytosol
- H+CHEBI:15378, H, cytosol
Outputs
- UMPCHEBI:57865, C9H11N2O9P, cytosol
- CO2CHEBI:16526, CO2, cytosol
Catalysed by
- orotidine-5'-phosphate decarboxylase activity of UMPS dimer [cytosol]EC 4.1.1.23
Literature
- Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria families Am J Hum Genet, 1997
- Intrinsic activity and stability of bifunctional human UMP synthase and its two separate catalytic domains, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase J Biol Chem, 1996
- Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design Structure, 2008
- Isolation and initial characterization of the single polypeptide that synthesizes uridine 5'-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5'-monophosphate synthase Biochemistry, 1980