Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi

N-Formyl-GAR + L-Gln + ATP + H2O → FGAM + L-Glu + ADP + Pi + H+

Reactome: R-HSA-73812
Compartment: cytosol
Rhea: RHEA:17130

Inputs

N-Formyl-GARCHEBI:147286, C8H13N2O9P, cytosol
L-GlnCHEBI:58359, C5H10N2O3, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

FGAMCHEBI:147287, C8H15N3O8P, cytosol
L-GluCHEBI:29985, C5H8NO4, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol
PiCHEBI:43474, HO4P, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

phosphoribosylformylglycinamidine synthase activity of PFAS [cytosol]EC 6.3.5.3; UniProt O15067

FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi

Inputs

Outputs

Catalysed by

Literature