5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi
PRA + Gly + ATP → PRGA + ADP + Pi + H+
- Reactome
- R-HSA-73814
- Compartment
- cytosol
- Rhea
- RHEA:17454
Inputs
- PRACHEBI:58681, C5H11NO7P, cytosol
- GlyCHEBI:57305, C2H5NO2, cytosol
- ATPCHEBI:30616, C10H12N5O13P3, cytosol
Outputs
- PRGACHEBI:143788, C7H14N2O8P, cytosol
- ADPCHEBI:456216, C10H12N5O10P2, cytosol
- PiCHEBI:43474, HO4P, cytosol
- H+CHEBI:15378, H, cytosol
Catalysed by
- phosphoribosylamine-glycine ligase activity of GART [cytosol]EC 6.3.4.13; UniProt P22102
Literature
- De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementation in E. coli Nucleic Acids Res, 1990
- Localization of GAR transformylase in Escherichia coli and mammalian cells Proc Natl Acad Sci USA, 2001
- Reversible compartmentalization of de novo purine biosynthetic complexes in living cells Science, 2008