CAIR + Aspartate + ATP => SAICAR + ADP + Pi
CAIR + L-Asp + ATP → SAICAR + ADP + Pi + 2 H+
- Reactome
- R-HSA-73805
- Compartment
- cytosol
- Rhea
- RHEA:22629
Inputs
- CAIRCHEBI:77657, C9H12N3O9P, cytosol
- L-AspCHEBI:29991, C4H6NO4, cytosol
- ATPCHEBI:30616, C10H12N5O13P3, cytosol
Outputs
- SAICARCHEBI:58443, C13H15N4O12P, cytosol
- ADPCHEBI:456216, C10H12N5O10P2, cytosol
- PiCHEBI:43474, HO4P, cytosol
- 2 H+CHEBI:15378, H, cytosol
Catalysed by
- phosphoribosylaminoimidazolesuccinocarboxamide synthase activity of PAICS octamer [cytosol]EC 6.3.2.6
Literature
- Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations Proc Natl Acad Sci USA, 1990
- Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis J Mol Biol, 2007
- Reversible compartmentalization of de novo purine biosynthetic complexes in living cells Science, 2008