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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate

XMP + L-Gln + ATP + H2O → GMP + L-Glu + 2 H+ + AMP + PPi

Reactome: R-HSA-73792
Compartment: cytosol
Rhea: RHEA:11681

Inputs

XMPCHEBI:57464, C10H11N4O9P, cytosol
L-GlnCHEBI:58359, C5H10N2O3, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

GMPCHEBI:58115, C10H12N5O8P, cytosol
L-GluCHEBI:29985, C5H8NO4, cytosol
2 H+CHEBI:15378, H, cytosol
AMPCHEBI:456215, C10H12N5O7P, cytosol
PPiCHEBI:33019, HO7P2, cytosol

Catalysed by

GMP synthase (glutamine-hydrolyzing) activity of GMPS [cytosol]EC 6.3.5.2; UniProt P49915

Literature

Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA J Biol Chem, 1994
Biochemical characterization of human GMP synthetase J Biol Chem, 1995