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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

DHODH:FMN oxidises (S)-DHO to orotate

(S)-DHO + CoQ → ORO + QH2

Reactome: R-HSA-73569
Compartment: cytosol · mitochondrial inner membrane
Rhea: RHEA:28692

Inputs

(S)-DHOCHEBI:30864, C5H5N2O4, cytosol
CoQCHEBI:46245, C59H90O4, mitochondrial inner membrane

Outputs

OROCHEBI:30839, C5H3N2O4, cytosol
QH2CHEBI:17976, (C5H8)n.C9H12O4, mitochondrial inner membrane

Catalysed by

dihydroorotate dehydrogenase activity of DHODH:FMN [mitochondrial inner membrane]EC 1.3.5.2

Literature

Pyrimidine nucleotide biosynthesis in animals: genes, enzymes, and regulation of UMP biosynthesis. Annu Rev Biochem, 1980
Superoxide production and electron transport in mitochondrial oxidation of dihydroorotic acid. J Biol Chem, 1975
Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase. Protein Expr Purif, 1998
Indirect inhibition of mitochondrial dihydroorotate dehydrogenase activity by nitric oxide. Free Radic Biol Med, 2000
Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydro-orotic dehydrogenase Biochim Biophys Acta, 1953