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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SAICAR => AICAR + Fumarate

SAICAR → AICAR + FUMA

Reactome: R-HSA-73800
Compartment: cytosol
Rhea: RHEA:23921

Inputs

SAICARCHEBI:58443, C13H15N4O12P, cytosol

Outputs

AICARCHEBI:58475, C9H13N4O8P, cytosol
FUMACHEBI:29806, C4H2O4, cytosol

Catalysed by

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity of ADSL tetramer [cytosol]EC 4.3.2.2

Literature

Expression, purification, and kinetic characterization of recombinant human adenylosuccinate lyase J Biol Chem, 1993
Clinical, biochemical and molecular genetic correlations in adenylosuccinate lyase deficiency Hum Mol Genet, 2000
Reversible compartmentalization of de novo purine biosynthetic complexes in living cells Science, 2008