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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AIR + CO2 => CAIR

AIR + CO2 → CAIR + H+

Reactome: R-HSA-73806
Compartment: cytosol
Rhea: RHEA:10794

Inputs

AIRCHEBI:137981, C8H13N3O7P, cytosol
CO2CHEBI:16526, CO2, cytosol

Outputs

CAIRCHEBI:77657, C9H12N3O9P, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

phosphoribosylaminoimidazole carboxylase activity of PAICS octamer [cytosol]EC 4.1.1.21

Literature

Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations Proc Natl Acad Sci USA, 1990
Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis J Mol Biol, 2007
Reversible compartmentalization of de novo purine biosynthetic complexes in living cells Science, 2008