CAD hexamer transforms L-Gln to CAP
HCO3- + L-Gln + 2 ATP + H2O → CAP + L-Glu + 2 ADP + Pi + 2 H+
- Reactome
- R-HSA-73577
- Compartment
- cytosol
- Rhea
- RHEA:18634
Inputs
- HCO3-CHEBI:17544, CHO3, cytosol
- L-GlnCHEBI:58359, C5H10N2O3, cytosol
- 2 ATPCHEBI:30616, C10H12N5O13P3, cytosol
- H2OCHEBI:15377, H2O, cytosol
Outputs
- CAPCHEBI:58228, CH2NO5P, cytosol
- L-GluCHEBI:29985, C5H8NO4, cytosol
- 2 ADPCHEBI:456216, C10H12N5O10P2, cytosol
- PiCHEBI:43474, HO4P, cytosol
- 2 H+CHEBI:15378, H, cytosol
Catalysed by
- carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity of CAD hexamer [cytosol]EC 6.3.5.5
Literature
- Control of pyrimidine biosynthesis in human lymphocytes. Simultaneous increase in activities of glutamine-utilizing carbamyl phosphate synthetase and aspartate transcarbamylase in phytohemagglutinin-stimulated human peripheral lymphocytes and their enzyme co-purification J Biol Chem, 1973
- Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis Biochem Biophys Res Commun, 1996