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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

IMPDH tetramers bind IMPDH inhibitors

IMPDH tetramers + IMPDH inhibitors → IMPDH tetramers:IMPDH inhibitors

Reactome: R-HSA-9678749
Compartment: cytosol
Rhea: None recorded

Inputs

IMPDH tetramersR-HSA-500309, cytosol
IMPDH inhibitorsR-ALL-9678719, cytosol

Outputs

IMPDH tetramers:IMPDH inhibitorsR-HSA-9679104, cytosol

Literature

Synthesis and immunosuppressive activity of some side-chain variants of mycophenolic acid J. Med. Chem., 1990
Thioguanine, mercaptopurine: their analogs and nucleosides as antimetabolites Curr. Pharm. Des., 2003
IMP dehydrogenase basal activity in MOLT-4 human leukaemia cells is altered by mycophenolic acid and 6-thioguanosine Scand. J. Clin. Lab. Invest., 2008
Mechanism of action of ribavirin in a novel hepatitis C virus replication cell system Virus Res., 2011
Mechanism of action of ribavirin in the treatment of chronic hepatitis C Gastroenterol Hepatol (N Y), 2007