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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Fatty acyl-CoA biosynthesis

Coenzyme-A ligation that activates fatty acids for downstream transformation. 25 reactions, from Reactome R-HSA-75105.

  1. Formation of fatty acid synthase (FAS) dimer2 FASN → FASN dimer
  2. Formation of Malonyl-CoA from Acetyl-CoA (liver)Ac-CoA + ATP + HCO3- → ADP + Pi + Mal-CoA + H+
  3. ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoAATP + CoA-SH + PALM → AMP + H2O + PALM-CoA + PPi
  4. ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoAAA-CoA + Mal-CoA + H+ → 3ODCT-CoA + CoA-SH + CO2
  5. ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoAPALM-CoA + Mal-CoA + H+ → 3OOD-CoA + CoA-SH + CO2
  6. ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoAICS-CoA + Mal-CoA + H+ → CoA-SH + CO2 + 3ODC-CoA
  7. HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA3OOD-CoA + NADPH + H+ → 3HODC-CoA + NADP+
  8. ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoATCS-CoA + Mal-CoA + H+ → 3OHC-CoA + CoA-SH + CO2
  9. TECR,TECRL dehydrogenate TOD-CoA to ST-CoATOD-CoA + NADPH + H+ → ST-CoA + NADP+
  10. ACSL3,4 ligate CoA to AA to form AA-CoAAA + ATP + CoA-SH → AA-CoA + AMP + PPi + H2O
  11. OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer2 H2O + decanoyl-FASN dimer → 2 DECA + FASN dimer + 2 H+
  12. PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoAVLC3HA-CoA → 2,3-TE-CoA + H2O
  13. PPT2 hydrolyses PALMCoA to PALMPALM-CoA + H2O → PALM + CoA-SH + H+
  14. PPT1 hydrolyses palmitoylated proteinsPALM:protein + H2O → PALM + protein + H+
  15. SCD desaturates ST-CoA to OLE-CoAST-CoA + 2 H+ + O2 + 2 Fe(2+)Cb5 → OLE-CoA + 2 Fe(3+)Cb5 + 2 H2O
  16. ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoAVLCFA + ATP + CoA-SH → VLCFA-CoA + AMP + PPi
  17. ACSF3 ligates CoA-SH to VLCFAVLCFA + ATP + CoA-SH → VLCFA-CoA + AMP + PPi
  18. ACLY tetramer transforms CIT to Ac-CoACIT + CoA-SH + ATP → Ac-CoA + ADP + OA + Pi
  19. Conversion of malonyl-CoA and acetyl-CoA to palmitateAc-CoA + 7 Mal-CoA + 14 NADPH + 14 H+ → PALM + 7 CO2 + 14 NADP+ + 8 CoA-SH + 6 H2O
  20. SCD5 desaturates ST-CoA to OLE-CoAST-CoA + 2 H+ + O2 + 2 Fe(2+)Cb5 → OLE-CoA + 2 Fe(3+)Cb5 + 2 H2O
  21. 2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACPNADPH + H+ + 3OA-ACP → NADP+ + 3HA-ACP
  22. SLC27A3 ligates CoA-SH to VLCFAATP + CoA-SH + VLCFA → VLCFA-CoA + AMP + PPi
  23. RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA3HA-CoA → t2E-CoA + H2O
  24. SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoAbempedoic acid + CoA-SH + ATP → ETC-1002-CoA + AMP + PPi
  25. ACLY tetramer binds ETC-1002-CoAACLY tetramer + ETC-1002-CoA → ACLY tetramer:ETC-1002-CoA