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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Di-/triphosphate interconversion

Phosphate-transfer reactions that balance nucleoside diphosphate and triphosphate pools. 34 reactions, from Reactome R-HSA-499943.

  1. (d)GDP + ADP (d)GMP + ATP (GUK1)(d)GDP + ADP → (d)GMP + ATP
  2. (d)ADP or (d)CDP + ADP (d)AMP or (d)CMP + ATP(d)NDPs + ADP → (d)NMPs + ATP
  3. AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs(d)NMPs + ATP → (d)NDPs + ADP
  4. (d)ADP + ADP (d)AMP + ATP (AK1)(d)ADP + ADP → (d)AMP + ATP
  5. ADP + ADP AMP + ATP [AK2]2 ADP → AMP + ATP
  6. AMP + ATP ADP + ADP [AK2]AMP + ATP → 2 ADP
  7. RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)NDP(3-) + GLRX → dNDP(3-) + 2xHC-GLRX + H2O
  8. glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)2xHC-GLRX + 2 GSH → GLRX + GSSG
  9. RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)NDP(3-) + TXN → dNDP(3-) + 2xHC-TXN + H2O
  10. RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)NDP(3-) + TXN → dNDP(3-) + 2xHC-TXN + H2O
  11. (d)NDP + ATP (d)NTP + ADP (NME1,2,3)(d)NDP + ATP → (d)NTP + ADP
  12. (d)NTP + ADP (d)NDP + ATP (NME1,2,3)(d)NTP + ADP → (d)NDP + ATP
  13. (d)NDP + ATP (d)NTP + ADP (NME4)(d)NDP + ATP → (d)NTP + ADP
  14. (d)NTP + ADP (d)NDP + ATP (NME4)(d)NTP + ADP → (d)NDP + ATP
  15. Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS2)UTP + ATP + L-Gln + H2O → CTP + ADP + L-Glu + Pi + 2 H+
  16. DCTPP1 hydrolyses 5idCTP5idCTP + H2O → 5idCMP + PPi + H+
  17. AK4 phosphorylates (d)NMPs to (d)NDPs(d)NMPs + ATP → (d)NDPs + ADP
  18. AK6 phosphorylates (d)NMPs to (d)NDPs(d)NMPs + ATP → (d)NDPs + ADP
  19. NME1:NME3 heterohexamer phosphorylates NDPs to NTPsATP + NDP(3-) → ADP + NTP
  20. NUDT13 hydrolyses AP6A to AP4 and ADPAP6A + H2O → AP4 + ADP + 2 H+
  21. glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+GSSG + NADPH + H+ → 2 GSH + NADP+
  22. (d)CMP or UMP + ATP (d)CDP or UDP + ADP (CMPK1)(d)CMP, UMP + ATP → (d)CDP, UDP + ADP
  23. dCMP + H2O => dUMP + NH4+dCMP + H2O + H+ → dUMP + NH4+
  24. conversion of dUMP to dTMPdUMP + 5,10-methylenetetrahydrofolate(2-) → DHF + TMP
  25. dUMP or TMP + ATP dUDP or TDP + ADP [DTYMK]dUMP, TMP + ATP → dUDP, TDP + ADP
  26. Regeneration of active (reduced) Thioredoxin2xHC-TXN + NADPH + H+ → TXN + NADP+
  27. Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS)ATP + H2O + L-Gln + UTP → ADP + CTP + L-Glu + Pi + 2 H+
  28. hydrolysis of 2'-deoxyuridine 5'-triphosphate to form 2'-deoxyuridine 5'-phosphatedUTP + H2O → dUMP + PPi + H+
  29. (d)GMP + ATP (d)GDP + ADP (GUK1)(d)GMP + ATP → (d)GDP + ADP
  30. (d)AMP + ATP (d)ADP + ADP (AK1)(d)AMP + ATP → (d)ADP + ADP
  31. (d)CDP or UDP + ADP (d)CMP or UMP + ATP (CMPK1)(d)CDP, UDP + ADP → (d)CMP, UMP + ATP
  32. dUDP or TDP + ADP dUMP or TMP + ATP [DTYMK]dUDP, TDP + ADP → dUMP, TMP + ATP
  33. RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)NDP(3-) + GLRX → dNDP(3-) + 2xHC-GLRX + H2O
  34. NME6 phosphorylates (d)NDPs to (d)NTPs(d)NDP + ATP → (d)NTP + ADP