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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs

(d)NMPs + ATP → (d)NDPs + ADP

Reactome: R-HSA-110138
Compartment: cytosol
Rhea: RHEA:23101, RHEA:12974, RHEA:11601, RHEA:25095

Inputs

(d)NMPsR-ALL-6788778, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

(d)NDPsR-ALL-6788782, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol

Catalysed by

nucleoside kinase activity of AK5,7,8,9 [cytosol]

Literature

Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein Eur J Biochem, 1999
The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes Biochem. J., 2011
The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase Int. J. Biochem. Cell Biol., 2013