Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AK6 phosphorylates (d)NMPs to (d)NDPs

(d)NMPs + ATP → (d)NDPs + ADP

Reactome: R-HSA-6788810
Compartment: nucleoplasm
Rhea: RHEA:23101, RHEA:12974, RHEA:11601, RHEA:25095

Inputs

(d)NMPsR-ALL-6788813, nucleoplasm
ATPCHEBI:30616, C10H12N5O13P3, nucleoplasm

Outputs

(d)NDPsR-ALL-6788807, nucleoplasm
ADPCHEBI:456216, C10H12N5O10P2, nucleoplasm

Catalysed by

nucleoside monophosphate kinase activity of AK6 [nucleoplasm]EC 2.7.4.4; UniProt Q9Y3D8

Literature

The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus Proc. Natl. Acad. Sci. U.S.A., 2005