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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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conversion of dUMP to dTMP

dUMP + 5,10-methylenetetrahydrofolate(2-) → DHF + TMP

Reactome
R-HSA-73605
Compartment
cytosol
Rhea
RHEA:12105

Inputs

Outputs

Catalysed by

  • thymidylate synthase activity of TS dimer [cytosol]EC 2.1.1.45

Literature

  1. Expression of human thymidylate synthase in Escherichia coli J Biol Chem, 1989
  2. Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors J Biol Chem, 2001