Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

(d)NTP + ADP (d)NDP + ATP (NME4)

(d)NTP + ADP → (d)NDP + ATP

Reactome: R-HSA-482812
Compartment: mitochondrial matrix · mitochondrial inner membrane
Rhea: RHEA:27676, RHEA:27688, RHEA:25239, RHEA:25100, RHEA:27692, RHEA:27680, RHEA:27684, RHEA:28584

Inputs

(d)NTPR-ALL-482807, mitochondrial matrix
ADPCHEBI:456216, C10H12N5O10P2, mitochondrial matrix

Outputs

(d)NDPR-ALL-482803, mitochondrial matrix
ATPCHEBI:30616, C10H12N5O13P3, mitochondrial matrix

Catalysed by

nucleoside diphosphate kinase activity of NME4 hexamer [mitochondrial inner membrane]EC 2.7.4.6

(d)NTP + ADP (d)NDP + ATP (NME4)

Inputs

Outputs

Catalysed by

Literature