Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS)
ATP + H2O + L-Gln + UTP → ADP + CTP + L-Glu + Pi + 2 H+
- Reactome
- R-HSA-73647
- Compartment
- cytosol
- Rhea
- RHEA:26427
Inputs
- ATPCHEBI:30616, C10H12N5O13P3, cytosol
- H2OCHEBI:15377, H2O, cytosol
- L-GlnCHEBI:58359, C5H10N2O3, cytosol
- UTPCHEBI:46398, C9H11N2O15P3, cytosol
Outputs
- ADPCHEBI:456216, C10H12N5O10P2, cytosol
- CTPCHEBI:37563, C9H12N3O14P3, cytosol
- L-GluCHEBI:29985, C5H8NO4, cytosol
- PiCHEBI:43474, HO4P, cytosol
- 2 H+CHEBI:15378, H, cytosol
Catalysed by
- CTP synthase activity of CTPS tetramer [cytosol]EC 6.3.4.2
Literature
- Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A J Biol Chem, 2005
- Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006