RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)
NDP(3-) + TXN → dNDP(3-) + 2xHC-TXN + H2O
- Reactome
- R-HSA-111751
- Compartment
- cytosol
- Rhea
- RHEA:23254
Inputs
- NDP(3-)CHEBI:57930, C5H8O10P2R, cytosol
- TXNR-HSA-66000, cytosol
Outputs
- dNDP(3-)CHEBI:73316, C5H8O9P2R, cytosol
- 2xHC-TXNR-HSA-73668, cytosol
- H2OCHEBI:15377, H2O, cytosol
Catalysed by
- ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor of RNR (M1M2) [cytosol]EC 1.17.4.1
Literature
- Structure and function of the radical enzyme ribonucleotide reductase Prog Biophys Mol Biol, 2001
- Thioredoxin and glutaredoxin systems J Biol Chem, 1989
- Ribonucleotide reductases Annu Rev Biochem, 2006
- Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage Proc. Natl. Acad. Sci. U.S.A., 2008
- Cross-talk between the allosteric effector-binding sites in mouse ribonucleotide reductase J Biol Chem, 2000
- The NMR solution structure of human glutaredoxin in the fully reduced form J Mol Biol, 1998