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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AK4 phosphorylates (d)NMPs to (d)NDPs

(d)NMPs + ATP → (d)NDPs + ADP

Reactome: R-HSA-6788798
Compartment: mitochondrial matrix
Rhea: RHEA:12974, RHEA:23101, RHEA:11601, RHEA:25095

Inputs

(d)NMPsR-ALL-6788802, mitochondrial matrix
ATPCHEBI:30616, C10H12N5O13P3, mitochondrial matrix

Outputs

(d)NDPsR-ALL-6788801, mitochondrial matrix
ADPCHEBI:456216, C10H12N5O10P2, mitochondrial matrix

Catalysed by

nucleoside monophosphate kinase activity of AK4 [mitochondrial matrix]EC 2.7.4.4; UniProt P27144

Literature

Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4 Int. J. Biochem. Cell Biol., 2010