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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NUDT13 hydrolyses AP6A to AP4 and ADP

AP6A + H2O → AP4 + ADP + 2 H+

Reactome: R-HSA-6810472
Compartment: mitochondrial matrix
Rhea: RHEA:51725

Inputs

AP6ACHEBI:63740, C20H24N10O25P6, mitochondrial matrix
H2OCHEBI:15377, H2O, mitochondrial matrix

Outputs

AP4CHEBI:58450, C10H12N5O16P4, mitochondrial matrix
ADPCHEBI:456216, C10H12N5O10P2, mitochondrial matrix
2 H+CHEBI:15378, H, mitochondrial matrix

Catalysed by

pyrophosphatase activity of NUDT13 [mitochondrial matrix]EC 3.6.1; UniProt Q86X67

Literature

Cloning and characterization of AtNUDT13, a novel mitochondrial Arabidopsis thaliana Nudix hydrolase specific for long-chain diadenosine polyphosphates FEBS J., 2007