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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

(d)GDP + ADP (d)GMP + ATP (GUK1)

(d)GDP + ADP → (d)GMP + ATP

Reactome: R-HSA-110133
Compartment: cytosol
Rhea: RHEA:12699, RHEA:20782

Inputs

(d)GDPR-ALL-500077, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol

Outputs

(d)GMPR-ALL-500071, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Catalysed by

GMP kinase activity of GUK1 [cytosol]EC 2.7.4.8; UniProt Q16774

Literature

Guanylate kinases from human erythrocytes, hog brain, and rat liver Methods Enzymol, 1978
Cloning, characterization, and modeling of mouse and human guanylate kinases J Biol Chem, 1996
Studies on the properties and tissue distribution of the isozymes of guanylate kinase in man Human Hered, 1975
Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase J Biol Chem, 1980