(d)NDP + ATP (d)NTP + ADP (NME1,2,3)

(d)NDP + ATP → (d)NTP + ADP

Reactome

R-HSA-482619

Compartment

cytosol

Rhea

RHEA:27687, RHEA:28583, RHEA:25238, RHEA:25099, RHEA:27675, RHEA:27691, RHEA:27679, RHEA:27683

Catalysed by

• nucleoside diphosphate kinase activity of NME1,2 hexamers [cytosol]EC 2.7.4.6

Literature

1. Enzymatic phosphorylation of nucleoside diphosphates J Biol Chem, 1954
2. Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases J Mol Biol, 2003
3. Structural and catalytic properties and homology modelling of the human nucleoside diphosphate kinase C, product of the DRnm23 gene Eur J Biochem, 2001
4. Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme J Biol Chem, 1991
5. Substrate specificity of human nucleoside-diphosphate kinase revealed by transient kinetic analysis J Biol Chem, 1998