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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS2)

UTP + ATP + L-Gln + H2O → CTP + ADP + L-Glu + Pi + 2 H+

Reactome: R-HSA-504054
Compartment: cytosol
Rhea: RHEA:26427

Inputs

UTPCHEBI:46398, C9H11N2O15P3, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol
L-GlnCHEBI:58359, C5H10N2O3, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

CTPCHEBI:37563, C9H12N3O14P3, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol
L-GluCHEBI:29985, C5H8NO4, cytosol
PiCHEBI:43474, HO4P, cytosol
2 H+CHEBI:15378, H, cytosol

Catalysed by

CTP synthase activity of CTPS2 tetramer [cytosol]EC 6.3.4.2

Literature

Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A J Biol Chem, 2005
Identification of a cDNA encoding an isoform of human CTP synthetase Biochim Biophys Acta, 2000