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Glycolysis
Cytosolic conversion of glucose-derived carbon to pyruvate, coupled to adenine-nucleotide and nicotinamide chemistry. 23 reactions, from Reactome R-HSA-70171.
- PP2A complex dephosphorylates pPFKFB1p-PFKFB1 dimer + 2 H2O → PFKFB1 dimer + 2 Pi
- PKA tetramer:cAMP phosphorylates PF2K-PasePFKFB1 dimer + 2 ATP → p-PFKFB1 dimer + 2 ADP + 2 H+
- NPC transports GCK1:GCKR from cytosol to nucleoplasmGCK1:GCKR complex → GCK1:GCKR complex
- cytosolic GCK1:GKRP complex glucokinase (GCK1) + glucokinase regulatory protein (GKRP)GCK1:GCKR complex → GCK + GCKR
- nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR)GCK1:GCKR complex → GCK + GCKR
- glucokinase (GCK1) + glucokinase regulatory protein (GKRP) GCK1:GKRP complexGCK + GCKR → GCK1:GCKR complex
- NPC exports GCK1 from nucleusGCK → GCK
- ADPGK:Mg2+ phosphorylates Glc to G6PGlc + ADP → G6P + AMP + H+
- BPGM dimer isomerises 1,3BPG to 2,3BPG1,3BPG → 2,3BPG + H+
- GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)PGlcN6P + H2O → Fru(6)P + NH4+
- PFKFKB dimer dephosphorylates fructose 2,6-bisphosphateD-Fructose 2,6-bisphosphate + H2O → Fru(6)P + Pi
- HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6PATP + Glc → ADP + G6P + H+
- GADPH tetramer dehydrogenates GA3PGA3P + Pi + NAD+ → 1,3BPG + NADH + H+
- TPI1 dimer isomerizes DHAP to GA3PDHAP → GA3P
- PFK tetramer phosphorylates Fru(6)PFru(6)P + ATP → F1,6PP + ADP + H+
- GPI dimer isomerizes G6PG6P → Fru(6)P
- Aldolase tetramer cleaves F1,6PPF1,6PP → DHAP + GA3P
- PGAM dimers isomerise 3PG to 2PG3PG → 2PG
- Enolase dimers dehydrates 2PG2PG → PEP + H2O
- Pyruvate kinase dephosphorylates PEP to PYRADP + PEP + H+ → ATP + PYR
- PFKFKB dimer phosphorylates Fru(6)PFru(6)P + ATP → D-Fructose 2,6-bisphosphate + ADP + H+
- PGK complexes dephosphorylate 1,3BPG1,3BPG + ADP → 3PG + ATP
- PGM2L1:Mg2+ phosphorylates G6P to G1,6BPG6P + 1,3BPG → G1,6BP + 3PG + H+