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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Enolase dimers dehydrates 2PG

2PG → PEP + H2O

Reactome: R-HSA-71660
Compartment: cytosol
Rhea: RHEA:10165

Inputs

2PGCHEBI:58289, C3H4O7P, cytosol

Outputs

PEPCHEBI:58702, C3H2O6P, cytosol
H2OCHEBI:15377, H2O, cytosol

Catalysed by

phosphopyruvate hydratase activity of enolase dimer [cytosol]EC 4.2.1.11

Literature

Beta-enolase deficiency, a new metabolic myopathy of distal glycolysis Ann Neurol, 2001
Molecular cloning and nucleotide sequence of a full-length cDNA for human alpha enolase Proc Natl Acad Sci U S A, 1986
Complete amino acid sequence of the neurone-specific gamma isozyme of enolase (NSE) from human brain and comparison with the non-neuronal alpha form (NNE) Eur J Biochem, 1988
Disruption of a spermatogenic cell-specific mouse enolase 4 (eno4) gene causes sperm structural defects and male infertility Biol Reprod, 2013
Enolase isoenzymes in rat tissues. Electrophoretic, chromatographic, immunological and kinetic properties Biochim Biophys Acta, 1974
Tau-crystallin/alpha-enolase: one gene encodes both an enzyme and a lens structural protein J Cell Biol, 1988