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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PP2A complex dephosphorylates pPFKFB1

p-PFKFB1 dimer + 2 H2O → PFKFB1 dimer + 2 Pi

Reactome: R-HSA-163750
Compartment: cytosol
Rhea: RHEA:20630

Inputs

p-PFKFB1 dimerR-HSA-163745, cytosol
2 H2OCHEBI:15377, H2O, cytosol

Outputs

PFKFB1 dimerR-HSA-71786, cytosol
2 PiCHEBI:43474, HO4P, cytosol

Catalysed by

protein serine/threonine phosphatase activity of PP2A-ABdeltaC complex [cytosol]EC 3.1.3.16

Literature

A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis Proc Natl Acad Sci U S A, 2003