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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PGAM dimers isomerise 3PG to 2PG

3PG → 2PG

Reactome: R-HSA-71654
Compartment: cytosol
Rhea: RHEA:15903

Inputs

3PGCHEBI:58272, C3H4O7P, cytosol

Outputs

2PGCHEBI:58289, C3H4O7P, cytosol

Catalysed by

phosphoglycerate mutase activity of PGAM dimers [cytosol]EC 5.4.2.11

Literature

Sequence of the human erythrocyte phosphoglycerate mutase by microsequencer and mass spectrometry J Biol Chem, 1988
Phosphoglycerate mutase isozyme marker for tissue differentiation in man Am J Hum Genet, 1974
Phosphoglycerate mutase BB isoenzyme deficiency in a patient with non-spherocytic anemia: familial and metabolic studies Haematologica, 2005
The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency Am J Hum Genet, 1993