Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR)

GCK1:GCKR complex → GCK + GCKR

Reactome: R-HSA-170810
Compartment: nucleoplasm
Rhea: None recorded

Inputs

GCK1:GCKR complexR-HSA-170804, nucleoplasm

Outputs

GCKR-HSA-450102, nucleoplasm
GCKRR-HSA-170805, nucleoplasm

Catalysed by

glucose sensor activity of GCK1:GCKR complex [nucleoplasm]

Literature

Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase J Biol Chem, 1999