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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Aldolase tetramer cleaves F1,6PP

F1,6PP → DHAP + GA3P

Reactome: R-HSA-71496
Compartment: cytosol
Rhea: RHEA:14730

Inputs

F1,6PPCHEBI:32966, C6H10O12P2, cytosol

Outputs

DHAPCHEBI:57642, C3H5O6P, cytosol
GA3PCHEBI:59776, C3H5O6P, cytosol

Catalysed by

fructose-bisphosphate aldolase activity of aldolase tetramer [cytosol]EC 4.1.2.13

Literature

Diverse mutations in the aldolase B gene that underlie the prevalence of hereditary fructose intolerance Am J Hum Genet, 1995
Human skeletal-muscle aldolase: N-terminal sequence analysis of CNBr- and o-iodosobenzoic acid-cleavage fragments Arch Biochem Biophys, 1984
The complete amino acid sequence of human skeletal-muscle fructose-bisphosphate aldolase Biochem J, 1988