PFK tetramer phosphorylates Fru(6)P
Fru(6)P + ATP → F1,6PP + ADP + H+
- Reactome
- R-HSA-70467
- Compartment
- cytosol
- Rhea
- RHEA:16110
Inputs
- Fru(6)PCHEBI:57634, C6H11O9P, cytosol
- ATPCHEBI:30616, C10H12N5O13P3, cytosol
Outputs
- F1,6PPCHEBI:32966, C6H10O12P2, cytosol
- ADPCHEBI:456216, C10H12N5O10P2, cytosol
- H+CHEBI:15378, H, cytosol
Catalysed by
- 6-phosphofructokinase activity of PFK tetramer [cytosol]EC 2.7.1.11
Literature
- Cloning of a complete protein-coding sequence of human platelet-type phosphofructokinase isozyme from pancreatic islet. Biochem Biophys Res Commun, 1994
- Functional expression of human mutant phosphofructokinase in yeast: genetic defects in French Canadian and Swiss patients with phosphofructokinase deficiency Am J Hum Genet, 1995
- Isozymes of human phosphofructokinase in blood cells and cultured cell lines: molecular and genetic evidence for a trigenic system Blood, 1981
- Isozymes of human phosphofructokinase: identification and subunit structural characterization of a new system Proc Natl Acad Sci U S A, 1980
- Characterization of the enzymatic defect in late-onset muscle phosphofructokinase deficiency. New subtype of glycogen storage disease type VII. J Clin Invest, 1987