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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GADPH tetramer dehydrogenates GA3P

GA3P + Pi + NAD+ → 1,3BPG + NADH + H+

Reactome: R-HSA-70449
Compartment: cytosol
Rhea: RHEA:10301

Inputs

GA3PCHEBI:59776, C3H5O6P, cytosol
PiCHEBI:43474, HO4P, cytosol
NAD+CHEBI:57540, C21H26N7O14P2, cytosol

Outputs

1,3BPGCHEBI:57604, C3H4O10P2, cytosol
NADHCHEBI:57945, C21H27N7O14P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity of GAPDH tetramers [cytosol]EC 1.2.1.12

Literature

Members of the human glyceraldehyde-3-phosphate dehydrogenase-related gene family map to dispersed chromosomal locations. Genomics, 1989
Crystalline D-glyceraldehyde-3-phosphate dehydrogenase from rabbit muscle J Biol Chem, 1948
Isozymes of glyceraldehyde-3-phosphate dehydrogenase in man and other mammals. Ann Hum Genet, 1976
Isolation and complete sequence of a functional human glyceraldehyde-3-phosphate dehydrogenase gene J Biol Chem, 1988
Glyceraldehyde-3-phosphate dehydrogenase from human tissues. Methods Enzymol, 1983
Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells. J Androl, 2000