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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate

D-Fructose 2,6-bisphosphate + H2O → Fru(6)P + Pi

Reactome: R-HSA-70262
Compartment: cytosol
Rhea: RHEA:17290

Inputs

D-Fructose 2,6-bisphosphateCHEBI:58579, C6H10O12P2, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

Fru(6)PCHEBI:57634, C6H11O9P, cytosol
PiCHEBI:43474, HO4P, cytosol

Catalysed by

fructose-2,6-bisphosphate 2-phosphatase activity of p-PFKFB1 dimer [cytosol]EC 3.1.3.46

Literature

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme. Annu Rev Biochem, 1995