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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PFKFKB dimer phosphorylates Fru(6)P

Fru(6)P + ATP → D-Fructose 2,6-bisphosphate + ADP + H+

Reactome: R-HSA-71802
Compartment: cytosol
Rhea: RHEA:15654

Inputs

Fru(6)PCHEBI:57634, C6H11O9P, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

D-Fructose 2,6-bisphosphateCHEBI:58579, C6H10O12P2, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

6-phosphofructo-2-kinase activity of PFKFB dimers [cytosol]EC 2.7.1.105

Literature

Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase Biochem Biophys Res Commun, 1988
Expression of human placental-type 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase in various cells and cell lines Biochem Biophys Res Commun, 1998
The kinase activity of human brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is regulated via inhibition by phosphoenolpyruvate Arch Biochem Biophys, 2005
Cloning, expression and chromosomal localization of a human testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene Gene, 1999
Hormonal regulation of hepatic gluconeogenesis and glycolysis Annu Rev Biochem, 1988
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme. Annu Rev Biochem, 1995