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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P

GlcN6P + H2O → Fru(6)P + NH4+

Reactome: R-HSA-6799604
Compartment: cytosol
Rhea: RHEA:12173

Inputs

GlcN6PCHEBI:75989, C6H13NO8P, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

Fru(6)PCHEBI:57634, C6H11O9P, cytosol
NH4+CHEBI:28938, H4N, cytosol

Catalysed by

glucosamine-6-phosphate deaminase activity of GNPDA1,2 hexamers [cytosol]EC 3.5.99.6

Literature

Molecularly cloned mammalian glucosamine-6-phosphate deaminase localizes to transporting epithelium and lacks oscillin activity FASEB J., 1998
Cloning and functional characterization of GNPI2, a novel human homolog of glucosamine-6-phosphate isomerase/oscillin J. Cell. Biochem., 2003
Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study FEBS Lett., 2003