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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PGK complexes dephosphorylate 1,3BPG

1,3BPG + ADP → 3PG + ATP

Reactome: R-HSA-71850
Compartment: cytosol
Rhea: RHEA:14803

Inputs

1,3BPGCHEBI:57604, C3H4O10P2, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol

Outputs

3PGCHEBI:58272, C3H4O7P, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Catalysed by

phosphoglycerate kinase activity of PGK complexes [cytosol]EC 2.7.2.3

Literature

Characterization of phosphoglycerate kinase from human spermatozoa Fertil. Steril., 1976
Complete amino acid sequence of human phosphoglycerate kinase. Isolation and amino acid sequence of tryptic peptides. J Biol Chem, 1980
Complete amino acid sequence of human phosphoglycerate kinase. Cyanogen bromide peptides and complete amino acid sequence. J Biol Chem, 1980
Human testis-specific PGK gene lacks introns and possesses characteristics of a processed gene Nature, 1987
Human phosphoglycerate kinase. I. Crystallization and characterization of normal enzyme J Biol Chem, 1972