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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Nucleotide salvage

Recovery of bases and nucleosides into reusable nucleotide pools. 22 reactions, from Reactome R-HSA-8956321.

  1. (2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)Ade-Rib, dA + ATP → (d)AMP + ADP + H+
  2. deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)dA, dG + ATP → dAMP, dGMP + ADP + H+
  3. deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]dC, Thy-dRib, dU + ATP → dCMP, TMP, dUMP + ADP + H+
  4. cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]Cyt-Rib, Ura-Rib + ATP → CMP, UMP + ADP + H+
  5. PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose-1-phosphate to (deoxy)inosineHyp + R1P, dRibP → Pi + Ino, dI
  6. PNP catalyzes the conversion of guanine and (deoxy)ribose-1-phosphate to (deoxy)guanosineGua + R1P, dRibP → Pi + G, dG
  7. thymine or uracil + 2-deoxy-D-ribose 1-phosphate thymidine or deoxyuridine + orthophosphate [TYMP]Thy, Ura + dRibP → Thy-Rib, dU + Pi
  8. MAPDA hydrolyzes N6-methyl-AMP to IMP and methylamineH2O + N(6)-methyl-AMP(2-) + H+ → methylamine + IMP
  9. GMP + NADPH + 2 H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)GMP + NADPH + 2 H+ → NADP+ + NH4+ + IMP
  10. HDHD1:Mg2+ dephosphorylates PURIDPPURIDP + H2O → PURID + Pi
  11. (2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)Cyt-Rib, dC + ATP → (d)CMP + ADP + H+
  12. cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]Cyt-Rib, Ura-Rib + ATP → CMP, UMP + ADP + H+
  13. deamination of 2'-Deoxycytidine to 2'-DeoxyuridineCyt-Rib, dC + H2O + H+ → (d)Ura + NH4+
  14. phosphorylation of 2'-Deoxythymidine to dTMPThy-dRib + ATP → TMP + ADP + H+
  15. dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)dA, dG, dI + ATP → dAMP, dGMP, dIMP + ADP + H+
  16. APRT catalyzes the conversion of adenine to AMPAde + PRPP → AMP + PPi
  17. HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMPGua, Hyp + PRPP → GMP, IMP + PPi
  18. ADA catalyzes the deamination of (deoxy)adenosineAde-Rib, dA + H2O + H+ → Ino, dI + NH4+
  19. uracil + (deoxy)ribose 1-phosphate (deoxy)uridine + orthophosphate [UPP]Ura + R1P, dRibP → (d)Ura + Pi
  20. AMP + H2O => IMP + NH4+ (AMPD)AMP + H2O + H+ → NH4+ + IMP
  21. UCKL1 phosphorylates urindine, cytidineCyt-Rib, Ura-Rib + ATP → CMP, UMP + ADP + H+
  22. MAPDA hydrolyzes N6-methyl-dAMP to dIMP and methylamineH+ + H2O + N(6)-methyl-dAMP(2-) → dIMP + methylamine