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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)

Cyt-Rib, dC + ATP → (d)CMP + ADP + H+

Reactome: R-HSA-73598
Compartment: cytosol
Rhea: RHEA:46041, RHEA:24675

Inputs

Cyt-Rib, dCR-ALL-500829, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

(d)CMPR-ALL-500828, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

nucleoside kinase activity of DCK dimer [cytosol]

Literature

Deoxycytidine kinase from human leukemic spleen: preparation and characterization of the homogeneous enzyme Biochemistry, 1988
Cloning and expression of human deoxycytidine kinase cDNA Proc Natl Acad Sci USA, 1991
Human T-lymphoblast deoxycytidine kinase: purification and properties Biochemistry, 1989
Kinetic properties and inhibition of human T lymphoblast deoxycytidine kinase J Biol Chem, 1989
The intracellular localization of deoxycytidine kinase J Biol Chem, 1998
Structure of human dCK suggests strategies to improve anticancer and antiviral therapy Nat Struct Biol, 2003