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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)

Ade-Rib, dA + ATP → (d)AMP + ADP + H+

Reactome: R-HSA-109624
Compartment: cytosol
Rhea: RHEA:20825

Inputs

Ade-Rib, dAR-ALL-500173, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

(d)AMPR-ALL-500088, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

adenosine kinase activity of ADK [cytosol]EC 2.7.1.20

Literature

Regulation of deoxyadenosine and nucleoside analog phosphorylation by human placental adenosine kinase J Biol Chem, 1985
Effects of mutational loss of adenosine kinase and deoxycytidine kinase on deoxyATP accumulation and deoxyadenosine toxicity in cultured CEM human T-lymphoblastoid cells J Biol Chem, 1982
Structure of human adenosine kinase at 1.5 A resolution. Biochemistry, 1998
Purification and properties of human placental adenosine kinase J Biol Chem, 1979