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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GMP + NADPH + 2 H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)

GMP + NADPH + 2 H+ → NADP+ + NH4+ + IMP

Reactome: R-HSA-514604
Compartment: cytosol
Rhea: RHEA:17187

Inputs

GMPCHEBI:58115, C10H12N5O8P, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
2 H+CHEBI:15378, H, cytosol

Outputs

NADP+CHEBI:58349, C21H25N7O17P3, cytosol
NH4+CHEBI:28938, H4N, cytosol
IMPCHEBI:58053, C10H11N4O8P, cytosol

Catalysed by

GMP reductase activity of GMPR tetramers [cytosol]EC 1.7.1.7

Literature

NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties Int J Biochem Cell Biol, 2002
Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP J Mol Biol, 2006
Reaction mechanism and specificity of human GMP reductase. Substrates, inhibitors, activators, and inactivators J Biol Chem, 1979