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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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MAPDA hydrolyzes N6-methyl-AMP to IMP and methylamine

H2O + N(6)-methyl-AMP(2-) + H+ → methylamine + IMP

Reactome
R-HSA-2161187
Compartment
cytosol
Rhea
RHEA:16002

Inputs

Outputs

Catalysed by

  • N6-methyl-AMP deaminase activity of MAPDA:Zn [cytosol]

Literature

  1. Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates J Med Chem, 2011
  2. MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool J Biol Chem, 2020