Skip to content
DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
Data
100%

Loading the map…

MAPDA hydrolyzes N6-methyl-dAMP to dIMP and methylamine

H+ + H2O + N(6)-methyl-dAMP(2-) → dIMP + methylamine

Reactome
R-HSA-9731661
Compartment
cytosol
Rhea
None recorded

Inputs

Outputs

Catalysed by

  • N6-methyl-AMP deaminase activity of MAPDA:Zn [cytosol]

Literature

  1. Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates J Med Chem, 2011
  2. MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool J Biol Chem, 2020