UCKL1 phosphorylates urindine, cytidine
Cyt-Rib, Ura-Rib + ATP → CMP, UMP + ADP + H+
- Reactome
- R-HSA-8954327
- Compartment
- cytosol
- Rhea
- RHEA:24675, RHEA:16826
Inputs
- Cyt-Rib, Ura-RibR-ALL-500759, cytosol
- ATPCHEBI:30616, C10H12N5O13P3, cytosol
Outputs
- CMP, UMPR-ALL-500761, cytosol
- ADPCHEBI:456216, C10H12N5O10P2, cytosol
- H+CHEBI:15378, H, cytosol
Catalysed by
- uridine kinase activity of UCKL1 [cytosol]EC 2.7.1.48; UniProt Q9NWZ5
Literature
- Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase BMC Cell Biol., 2002
- Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma Biochem J, 1977
- Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases Mol Pharmacol, 2001