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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)

dA, dG, dI + ATP → dAMP, dGMP, dIMP + ADP + H+

Reactome: R-HSA-74207
Compartment: mitochondrial matrix
Rhea: RHEA:23453, RHEA:19202

Inputs

dA, dG, dIR-ALL-500224, mitochondrial matrix
ATPCHEBI:30616, C10H12N5O13P3, mitochondrial matrix

Outputs

dAMP, dGMP, dIMPR-ALL-500222, mitochondrial matrix
ADPCHEBI:456216, C10H12N5O10P2, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix

Catalysed by

deoxynucleoside kinase activity of DGUOK dimer [mitochondrial matrix]EC 2.7.1.145

Literature

Cloning and expression of human deoxyguanosine kinase cDNA Proc Natl Acad Sci USA, 1996
Properties of a highly purified mitochondrial deoxyguanosine kinase Arch Biochem Biophys, 1988
Structural basis for substrate specificities of cellular deoxyribonucleoside kinases Nat Struct Biol, 2001