Skip to content

DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

phosphorylation of 2'-Deoxythymidine to dTMP

Thy-dRib + ATP → TMP + ADP + H+

Reactome: R-HSA-73632
Compartment: cytosol
Rhea: RHEA:19130

Inputs

Thy-dRibCHEBI:17748, C10H14N2O5, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

TMPCHEBI:63528, C10H13N2O8P, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

nucleoside kinase activity of TK1 tetramer [cytosol]

Literature

Structure of a type II thymidine kinase with bound dTTP FEBS Lett, 2005
Human deoxythymidine kinase. I. Purification and general properties of the cytoplasmic and mitochondrial isozymes derived from blast cells of acute myelocytic leukemia J Biol Chem, 1976
Diverging substrate specificity of pure human thymidine kinases 1 and 2 against antiviral dideoxynucleosides J Biol Chem, 1991
Reversible ATP-dependent transition between two forms of human cytosolic thymidine kinase with different enzymatic properties J Biol Chem, 1993
Regulation of human thymidine kinase during the cell cycle J Biol Chem, 1988
Human cytosolic thymidine kinase. Purification and physical characterization of the enzyme from HeLa cells J Biol Chem, 1988