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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP

Gua, Hyp + PRPP → GMP, IMP + PPi

Reactome: R-HSA-74215
Compartment: cytosol
Rhea: RHEA:25426, RHEA:17975

Inputs

Gua, HypR-ALL-500259, cytosol
PRPPCHEBI:58017, C5H8O14P3, cytosol

Outputs

GMP, IMPR-ALL-500260, cytosol
PPiCHEBI:33019, HO7P2, cytosol

Catalysed by

purine phosphoribosyltransferase activity of HPRT1 tetramer [cytosol]

Literature

Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase Proc Natl Acad Sci U S A, 1983