Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose-1-phosphate to (deoxy)inosine

Hyp + R1P, dRibP → Pi + Ino, dI

Reactome: R-HSA-112033
Compartment: cytosol
Rhea: RHEA:27648, RHEA:27752

Inputs

HypCHEBI:17368, C5H4N4O, cytosol
R1P, dRibPR-ALL-500244, cytosol

Outputs

PiCHEBI:43474, HO4P, cytosol
Ino, dIR-ALL-500172, cytosol

Catalysed by

purine-nucleoside phosphorylase activity of PNP trimer [cytosol]EC 2.4.2.1

Literature

Characterization of purine nucleoside phosphorylase from human granulocytes and its metabolism of deoxyribonucleosides J Biol Chem, 1980
A human purine nucleoside phosphorylase deficiency caused by a single base change J Biol Chem, 1987
Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution J Biol Chem, 1990